Therapeutic Areas

Liver fibrosis is characterized by an excessive accumulation of extracellular matrix proteins including collagen that occurs in most types of chronic liver diseases, such as chronic viral disease (Hepatitis B or C) or fatty liver disease. If the fibrosis is left untreated normal liver tissue can be progressively replaced by fibrous scar tissue resulting in liver cirrhosis and portal hypertension. While currently available treatments for liver fibrosis are usually too toxic for long-term use (eg, corticosteroids, penicillamine) , ACROVIS is dedicated to discover new and innovative treatments for this life-threatening condition that bring fibrosis to a halt or even reverse the progression to cirrhosis.

Acute Renal failure (ARF) is characterized by a rapid fall in glomerular filtration rate, clinically manifest as an abrupt and sustained rise in blood urea and creatinine. Current treatment options are dialysis or a kidney transplant. Acute kidney failure is most common in people who are already hospitalized, particularly people who need intensive care. Acute kidney failure tends to occur after complicated surgery, after a severe injury, or when blood flow to the kidneys is disrupted and generally requires intensive treatment.  ACROVIS is working to develop new and effective approaches for the treatment of that serious condition.