Medicinal Chemistry

We have in-depth experience in a wide variety of synthetic organic transformations covering all phases of medicinal chemistry from early stage hit generation to late stage lead optimization. By implementing integrated solutions for protein structure-based drug discovery, our chemists interact closely with our our CADD group and our protein structure unit.
Our medicinal chemistry services include:
- Hit validation and evaluation
- Synthesis of back-up series
- Hit to lead using an iterative process guided by biological and structural data
- Lead optimization improving activity and selectivity
- Optimization of ADMET & PK
- Development of complex multi-step synthesis
- Synthesis of back-up series
- Development of IP strategies